AQP0 Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody

Supplier:  Bioss BS6661R

Catalog No. 50-198-7411

Description

AQP0 is the most abundant endogenous protein in the plasma membrane of lens fiber cells where it functions not only as a water pore, but it is also involved in fiber-fiber adhesion and is crucial for fiber cell structure and organization. AQP0 contains an additional pore constriction, not seen in any other aquaporin structures, which may be responsible for pore gating. The closed AQP0 pore holds just three water molecules, which are spaced too far apart to form hydrogen bonds with each other. The C-terminal domain of AQP0 undergoes extensive post-translational modification, including many truncations, during lens aging due to the actions of m-calpain, proteases or non-enzymatic mechanisms. These truncation sites may be involved in the development of cataracts.

Specifications

• Antigen: AQP0
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MIP
• Gene Alias: AQP0; aquaporin 0; Aquaporin0; Aquaporin-0; Cat; CTRCT15; dominant cataract; Hfi; hydropic fibers; Lens fiber major intrinsic protein; lens opacity; LIM1; Lop; major intrinsic protein of eye lens fiber; major intrinsic protein of lens fiber; MIP; MIP26; MP26; Palm; shrivelled; Svl
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 4284
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 μg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene Accession No.: P30301
• Gene Symbols: MIP
• Immunogen: KLH conjugated synthetic peptide derived from human AQP0.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG