AR Mouse anti-Human, Clone: OTI2H2, lyophilized, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene CF809115
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCOThe androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis.AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain.Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy ft.s disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).
|Human recombit protein fragment corresponding to amino acids 420-659 of human AR produced in E.coli.|
|PBS with 8% trehalose and no preservative; pH 7.3|
|AIS, AR8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM|
|-20° C, Avoid Freeze/Thaw Cycles|
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