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AR Mouse anti-Human, Clone: OTI2H2, lyophilized, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner CF809115

Catalog No. 50-166-9281


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis.AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain.Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy ft.s disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).
Specifications

Specifications

AR
Monoclonal
Unconjugated
AR
Lyophilized
AR
Human recombit protein fragment corresponding to amino acids 420-659 of human AR produced in E.coli.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Western Blot
OTI2H2
PBS with 8% trehalose and no preservative; pH 7.3
P10275
AIS, AR8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
367
SDS
Documents
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