Invitrogen™ Human ARC Synthetic Peptide

Synthetic Peptide

Supplier:  Invitrogen™ PEP0032

Catalog No. PEP0032

Description

ARC Synthetic Peptide, PEP-0032, from Invitrogen.

ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms. Isoform 1 is involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. ARC inhibits extrinsic apoptotic pathways two different ways. The first is by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly. The second way is by interacting with CASP8 in a mitochondria localization-and phosphorylation-dependent manner, which in turn limits the amount of soluble CASP8 avaliable for DISC-mediated activation. ARC also inhibits intrinsic apoptotic pathways in response to a wide range of stresses through interactions with BAX. This results in BAX inactivation and prevents mitochondrial dysfunction and release of pro-apoptotic factors. Mutations affecting the gene can results in myoclonus, familiam cortical. This peptide corresponds to 18 amino acids near the carboxy terminus of human ARC.PEP-0032 can be used as a blocking peptide with polyclonal antibody PA5-19906.

Specifications

• Gene ID (Entrez): 8996
• Purification Method: purified
• Common Name: Human ARC
• Content And Storage: -20°C
• Format: Liquid
• For Use With (Application): Blocking Assay, Control
• Lyophilized: No
• Product Type: Peptide
• Regulatory Status: RUO - research use only

• Species: Human
• Accession Number: O60936
• Concentration: 200 μg/mL
• Description: Synthetic Peptide
• Formulation: PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
• Gene Symbol: NOL3
• Preservative: 0.02% sodium azide
• Quantity: 50 μg
• Storage Buffer: PBS