Invitrogen™ Argonaute 3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA570415

Catalog No. PIPA570415

Description

This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%.

AGO3 (protein argonaute-3) is required to RNA-mediated gene silencing (RNAi). It binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. AGO3 is proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4.

Specifications

• Antigen: Argonaute 3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AGO3
• Gene Alias: AGO3; argonaute 3; argonaute 3, RISC catalytic component; argonaute RISC catalytic component 3; argonaute RISC catalytic subunit 3; argonaute3; AW048688; C130014L07Rik; eIF2C 3; eIF-2C 3; EIF2C1; EIF2C3; Eukaryotic translation initiation factor 2C 3; eukaryotic translation initiation factor 2C, 1; eukaryotic translation initiation factor 2C, 3; hAgo3; mAgo3; Piwi/Argonaute family protein meIF2C3; Protein argonaute-3
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 214150
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q8CJF9
• Gene Symbols: AGO3
• Immunogen: synthetic peptide directed towards the middle region of human Argonaut 3 (aa 160-209).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG