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ARH Mouse anti-Human, Clone: OTI4B10, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525755

Catalog No. PIMA525755


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Description

Description

LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. This adapter protein is required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). LDLRAP1 may be required for LDL binding and internalization but not for receptor clustering in coated pits. This protein may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits, and may also be involved in the internalization of other LDLR family members. Mutations in the LDLRAP1 gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.
Specifications

Specifications

ARH
Monoclonal
0.62 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q5SW96
ARH, ARH1, ARH2, FHCB1, FHCB2, LDL receptor adaptor protein, autosomal recessive hypercholesterolemia protein, low density lipoprotein receptor adapter protein 1
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
26119
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
OTI4B10
Unconjugated
LDLRAP1
Liquid
LDLRAP1
Full length human recombit protein of LDLRAP1 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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