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ARHGAP24 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA548640

Catalog No. PA548640


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Description

Description

Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
Specifications

Specifications

ARHGAP24
Polyclonal
PBS with 0.09% sodium azide
Q8N264
Rho GTPase-activating protein 24, Filamin-A-associated RhoGAP, FilGAP, RAC1- and CDC42-specific GTPase-activating protein of 72 kDa, RC-GAP72, Rho-type GTPase-activating protein 24, RhoGAP of 73 kDa, Sarcoma antigen NY-SAR-88, p73RhoGAP, ARHGAP24, FILGAP
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
83478
Western Blot
Unconjugated
ARHGAP24
Liquid
ARHGAP24
KLH conjugated synthetic peptide between 587-616 amino acids from the C-terminal region of human ARHGAP24.
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human
Documents
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