ARHGAP24 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA548640
DescriptionRho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
|PBS with 0.09% sodium azide|
|Rho GTPase-activating protein 24, Filamin-A-associated RhoGAP, FilGAP, RAC1- and CDC42-specific GTPase-activating protein of 72 kDa, RC-GAP72, Rho-type GTPase-activating protein 24, RhoGAP of 73 kDa, Sarcoma antigen NY-SAR-88, p73RhoGAP, ARHGAP24, FILGAP|
|-20° C, Avoid Freeze/Thaw Cycles|
|KLH conjugated synthetic peptide between 587-616 amino acids from the C-terminal region of human ARHGAP24.|
|Antigen Affinity Chromatography, Protein A|
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