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ARHGEF11 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550114

Catalog No. PA550114


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Description

Description

The antibody detects endogenous levels of total ARHGEF11 protein.

ARHGEF11 is a 1527 amino acid protein with tandem dbl homology and pleckstrin homology domains, PDZ domain, two proline rich sequences and a regulatory G protein-signaling (RGS) sequence. It acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase, but not for RAC1 or CDC42 and acts as GTPase-activating protein (GAP) for GNA12 and GNA13. It forms a complex with G proteins and stimulates neurite through retraction Rho-dependent signals. ARHGEF11 increases glutamate transport 4-fold. It interacts with EAAT4 and modulates its uptake activity and perisynaptic distribution at glutamatergic synapses. It is known to induce the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. It is ubiquitously expressed, in brain, lung, liver, kidney and skeletal muscle.
Specifications

Specifications

ARHGEF11
Polyclonal
Unconjugated
ARHGEF11
Liquid
ARHGEF11
Synthesized peptide derived from N-terminal of human ARHGEF11.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
O15085
KIAA0380
Rabbit
IgG
100 μL
-20°C
Primary
9826
Documents
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