Invitrogen™ ARHGEF17 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103351

Catalog No. PIPA5103351

Description

Antibody detects endogenous levels of total ARHGEF17.

Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically.

Specifications

• Antigen: ARHGEF17
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ARHGEF17
• Gene Alias: 164 kDa Rho-specific guanine-nucleotide exchange factor; 8030463K16; AI428794; Arhgef17; AW558066; BC035332; Kiaa0337; mKIAA0337; P164RHOGEF; p164-RhoGEF; Rho guanine nucleotide exchange factor (GEF) 17; Rho guanine nucleotide exchange factor 17; Rho-specific guanine-nucleotide exchange factor 164 kDa; TEM4; Tumor endothelial marker 4
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 207212, 9828
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q80U35, Q96PE2
• Gene Symbols: ARHGEF17
• Immunogen: A synthesized peptide derived from human ARHGEF17(Accession Q96PE2), corresponding to amino acid residues T1679-L1729.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov