ARHGEF18 Mouse anti-Human, Clone: OTI6D10, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527295
DescriptionActs as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950).
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|P114-RhoGEF, 114 kDa Rho-specific guanine nucleotide exchange factor, P114-RHO-GEF, Rho-specific guanine nucleotide exchange factor p114, Rho/Rac guanine nucleotide exchange factor 18, SA-RhoGEF, p114RhoGEF, rho guanine nucleotide exchange factor 18, septin-associated RhoGEF|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 118-215 of ARHGEF18 produced in E.coli|
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