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ARHGEF3 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550116

Catalog No. PA550116


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Description

Description

The antibody detects endogenous levels of total ARHGEF3 protein.

Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

ARHGEF3
Polyclonal
Unconjugated
ARHGEF3
Liquid
ARHGEF3
Synthesized peptide derived from internal of human ARHGEF3.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q9NR81, Q91X46
ARHG3, DKFZP434F2429, exchange factor found in platelets and leukemic and neuronal tissues, GEF3, MGC118905
Rabbit
IgG
100 μL
-20°C
Primary
50650, 71704
Documents
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