ARID1A Mouse anti-Human, Clone: GT3611, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527793
Positive Control: 293T Predicted Reactivity: Bovine (84%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.ARID1A encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.
|PBS with no preservative|
|OSA1, BAF250, BAF250a, ELD, AT rich interactive domain 1A (SWI-like), SMARCF1, C1orf4, P270, hELD, B120, hOSA1, BM029, MRD14|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Recombit protein encompassing a sequence within the C-terminus region of human ARID1A. The exact sequence is proprietary.|
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