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ARID1A Mouse anti-Human, Clone: CL3595, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524658

Catalog No. PIMA524658


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Description

Description

Immunogen sequence: PGLGNVAMGP RQHYPYGGPY DRVRTEPGIG PEGNMSTGAP QPNLMPSNPD SGMYSPSRYP PQQQQQQQQR HDSYGNQFST QGTPSGSPFP SQQTTMYQQQ QQNYK Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 88%. Binds to an epitope located within the peptide sequence VAMGPRQHYPYGGPY as determined by overlapping synthetic peptides.

This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Specifications

Specifications

ARID1A
Monoclonal
1 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
O14497
BAF250, C1orf4, AT rich interactive domain 1A SWI-like, B120, P270, SMARCF1, ELD, OSA1, hELD, hOSA1, BAF250a, MRD14, BM029
Mouse
IgG1
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
8289
Immunohistochemistry, Western Blot
CL3595
Unconjugated
ARID1A
Liquid
ARID1A
Recombit protein corresponding to Human ARID1A
Protein A
RUO
Antibody
Monoclonal
Human
Documents
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