ARID1A Mouse anti-Human, Clone: CL3595, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524658
Immunogen sequence: PGLGNVAMGP RQHYPYGGPY DRVRTEPGIG PEGNMSTGAP QPNLMPSNPD SGMYSPSRYP PQQQQQQQQR HDSYGNQFST QGTPSGSPFP SQQTTMYQQQ QQNYK Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 88%. Binds to an epitope located within the peptide sequence VAMGPRQHYPYGGPY as determined by overlapping synthetic peptides.This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
|PBS with 40% glycerol and 0.02% sodium azide; pH 7.2|
|BAF250, C1orf4, AT rich interactive domain 1A SWI-like, B120, P270, SMARCF1, ELD, OSA1, hELD, hOSA1, BAF250a, MRD14, BM029|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Immunohistochemistry, Western Blot|
|Recombit protein corresponding to Human ARID1A|
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