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ARID1B Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550918

Catalog No. PA550918


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Description

Description

ARID1B / BAF250B Polyclonal Antibody detects endogenous levels of ARID1B / BAF250B protein.

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Binds DNA non-specifically. {ECO:0000250}.
Specifications

Specifications

ARID1B
Polyclonal
Unconjugated
ARID1B
Liquid
ARID1B
Synthesized peptide derived from the Internal region of human BAF250b.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Rat
ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Q8NFD5
BAF250B, DAN15, KIAA1235, OSA2
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
282546, 57492
Documents
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