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ARL3 Mouse anti-Human, Clone: OTI2A9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526578

Catalog No. PIMA526578


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Description

Description

ADP-ribosylation factors (ARFs) are low molecular weight GTP-binding proteins belonging to the RAS superfamily. The predicted 182-amino acid ARL3 (ADP-ribosylation like factor) protein shares 97% amino acid identity with rat ARLl3 and 43% identity with human ARF1. Like the ARFs, ARL3 has a glycine at position 2, the site of N myristoylation, and lacks cysteine residues near the C terminus, which are found in other members of the RAS family. Northern blot analysis detected a 1-kb ARL3 transcript in all tissues tested, with highest expression in heart and lung, and lower expression in brain, liver, kidney, ovary, and testis. A 5.5-kb transcript was also detected in most tissues, with highest expression in brain. Immunoblot analysis detected ARL3 in human tumor cell lines but not in normal rodent cells. Although ARL3 binds GTP, it is devoid of activity in the cholera toxin-dependent ADP-ribosylation of Gs, and is therefore classified as an ARF-like protein.
Specifications

Specifications

ARL3
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P36405
ADP-ribosylation factor-like 3; ADP-ribosylation-like 3; Arf-like 3; Arf-like protein 3; ARFL3; Arl3
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
403
Immunohistochemistry (Paraffin), Western Blot
OTI2A9
Unconjugated
ARL3
Liquid
ARL3
Human recombit protein fragment corresponding to amino acids 2-182 of ARL3 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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