Tocris AS 1949490
SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) inhibitor
Manufacturer: Tocris 3718/10
DescriptionSelective SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2) inhibitor (IC50 values are 0.34µM and 0.62µM for mouse and human respectively); displays approximately 30-fold affinity for SHIP2 over SHIP1. Increases insulin-induced phosphorylation of Akt in L6 myotubules. Stimulates activation of glucose metabolism; regulates gluconeogenesis in vitro and in vivo and exhibits antidiabetic effects.
- Chemical Name: 3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide
- Formula: C20H18ClNO2S
- CAS Number: 1203680-76-5
- Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
- Purity: >99
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