Tocris AS 605240
Potent and selective PI 3-kinase gamma (PI 3-Kgamma) inhibitor
Manufacturer: Tocris 3578/10
DescriptionPotent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ) (IC50 = 8nM). Displays 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα. Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.
- Chemical Name: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
- Formula: C12H7N3O2S
- CAS Number: 648450-29-7
- Solubility: Soluble to 1mM in DMSO with gentle warming
- Purity: >98
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