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Tocris™ AS 605240

Potent and selective PI 3-kinase gamma (PI 3-Kgamma) inhibitor

Manufacturer:  Tocris™ 3578/10

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Catalog No. 35-781-0R

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For Research Use Only



Potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ) (IC50 = 8nM). Displays 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα. Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.
  • Chemical Name: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
  • Formula: C12H7N3O2S
  • CAS Number: 648450-29-7
  • Solubility: Soluble to 1mM in DMSO with gentle warming
  • Purity: >98
Description & Specifications


AS 605240
AS 605240
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