Tocris™ Asenapine maleate

Novel antipsychotic agent

Manufacturer: Tocris™ 3737/10

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Catalog No. 37-371-0R

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Disclaimers:

For Research Use Only


    Specifications

    Product Type Asenapine maleate
    Inhibitors Asenapine maleate
    Purity >98
    Molecular Weight 401.84
    Quantity 10mg

    Novel psychopharmacologic agent. Displays antagonist activity at 5-HT, dopamine, noradrenalin and histamine receptor subtypes (pKi values are 8.60, 8.40, 10.15, 9.75, 10.46, 8.84, 9.60, 9.94, 8.85, 8.90, 8.84, 9.38, 8.95, 8.93, 8.9, 9.49, 8.91, 9.00 and 8.21 for 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, 5-HT7, D1, D2L, D2S, D3, D4, α1A, α2A, α2B, α2C, H1 and H2 receptors respectively). Displays no appreciable affinity for muscarinic receptors. Exhibits potent activity in animal models predictive of antipsychotic efficacy.

    • Chemical Name: (3aR*,12bR*)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate
    • Formula: C17H16ClNO.C4H4O4
    • CAS Number: 85650-56-2
    • Solubility: Soluble to 100mM in DMSO and to 50mM in ethanol
    • Purity: >98

  • Description & Specifications

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