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ASH2L Rat anti-Human, Clone: 4C5, Active Motif™

Rat Monoclonal Antibody

Manufacturer:  Active MotifSupplier Diversity Partner 61359

Encompass

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Catalog No. 50-199-3342


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Description

Description

The human ASH2L gene encodes a 628 amino acid protein known as ASH2L1, or isoform 1, which contains a nuclear localization signal and PHD finger motif, suggesting that the gene product functions as a transcription regulator. Its predicted molecular weight is 68.7kDa. Alternative splicing results in possible isoforms at 60 kDa & 56.5 kDa). Human ASH2L proteins are 60% homologous to Drosophila ash2, which positively regulates expression of certain genes in early development, and contain similar, but not identical, domains, including a zinc finger motif. Homology to mouse ASH2L is 90%. ASH2L is predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes as well as leukemia cell lines with erythroid and megakaryocytic potential, such as K562, Hel and Dami. Differentiation inducers (e.g. phorbol ester and hemin) cause different expression patterns in these cell lines, suggesting that ASH2L plays a role in hematopoiesis and is associated with particular types of leukemia. In addition ASH2L has been suggested to interact with beta-tubulin and beta-catenin.
Specifications

Specifications

ASH2L
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
1 mg/mL
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Q9UBL3
ASH 2; ASH2; ash2 (absent, small, or homeotic)-like; ash2 (absent, small, or homeotic)-like (Drosophila); ASH2 LIKE; ASH2 like histone lysine methyltransferase complex subunit; ASH2 like protein; ASH2 like, histone lysine methyltransferase complex subunit; Ash2l; ASH2L1; ASH2L2; ash2-like; ASH2-like protein; BOS_23936; Bre 2; Bre2; LOC100338600; Set1/Ash2 histone methyltransferase complex subunit ASH2
This antibody was raised against a recombinant protein corresponding to the N-terminal region of human ASH2L.
Protein G
RUO
Antibody
Monoclonal
Human
ASH2L
4C5
Unconjugated
ASH2L
Liquid
Rat
IgG2a
100 μg
-20°C, Avoid Freeze/Thaw Cycles
Primary
9070
SDS
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