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ASIC1 Mouse anti-Mouse, Rat, Clone: S271-44, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527640

Catalog No. PIMA527640


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Description

Description

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. ASIC1 is permeable for Ca(2+), Li(+) and K(+) and is expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, neo and allocortical regions, dentate granule cells, pyramidal cells of CA1-CA3 subfields of the hippocampal formation, habenula, basolateral amygdaloid nuclei, and in the Purkinje and granule cells of the cerebellum. It is diffusely detected over most other regions of the basal ganglia, including thalamic nuclei, substantia nigra, striatum and globus pallidus, hypothalamus, midbrain, pons, medulla and choroid plexus. Isoform 3 is expressed only in dorsal root ganglion while isoform 1 is expressed in DRG, spinal chord, trigeminal ganglia and the trigeminal mesencephalic nucleus.
Specifications

Specifications

ASIC1
Monoclonal
1 mg/ml
PBS with 50% glycerol and 0.09% sodium azide; pH 7.4
P55926, Q6NXK8
ACCN2, Acid-sensing (proton-gated) ion channel, Acid-sensing ion channel 1, Amiloride-sensitive cation channel 2 neuronal, BNAC2, Brain sodium channel 2
Mouse
IgG1
100 μg
-20°C
Primary
11419, 79123
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
S271-44
Unconjugated
Asic1
Liquid
Asic1
Fusion protein amino acids 460-526 (Cytoplasmic C-terminus) of mouse ASIC1
Protein G
RUO
Antibody
Monoclonal
Mouse, Rat
Documents
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