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Tocris Bioscience™ AT 101 Inhibitor

Low molecular weight, organic compound that may help regulate biological process.

Specifications

For Use With (Application) Inhibits apoptosis
Solubility Soluble to 100mM in DMSO, 100mM in ethanol
Storage Requirements Store at −20°C
Target Proteins AT 101
Color Dark purple
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
NB336710MG View Documents Tocris Bioscience™
NB336710MG
10mg This item has been discontinued and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
NB336750MG View Documents Tocris Bioscience™
NB336750MG
50mg This item has been discontinued and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
Description

Description

Biological Activity:
R-(-)-enantiomer of gossypol. Mimics BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo.

Storage: Store the unopened product at 2° to 8°C. Do not use past expiration date.

Specifications

Specifications

Inhibits apoptosis
Store at −20°C
Dark purple
Soluble to 100mM in DMSO, 100mM in ethanol
AT 101

For Laboratory Research Use Only

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