Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. 69705TOC

Tocris Bioscience™ aTAG 2139
GREENER_CHOICE

Catalog No. 69705TOC
Change view
Click to view available options
Quantity:
5 mg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
69-705-TOC 5 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
This item is not returnable. View return policy
Catalog No. 69-705-TOC Supplier Tocris Bioscience™ Supplier No. 6970/5
Add to Cart
Add to Cart
This item is not returnable. View return policy

Description

Degrader of MTH1 fusion proteins for use within the aTAG system

aTAG 2139 is a degrader of MTH1 fusion proteins for use within the aTAG system. Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide (Cat. No. 0652). Induces highly potent and selective degradation of fusion proteins after a 4 h incubation (DC50 = 0.27 nM; Dmax = 92.1%). Cell-permeable. Suitable for in vitro and in vivo applications.

Negative control aTAG 2139-NEG (Cat. No. 7575) also available.

Mouse DMPK properties are provided in the supplementary file (see below).

MTH1 can be expressed as a fusion with a target protein of interest using genome engineering techniques via CRISPR-mediated locus-specific knock-in. See protocol for more information.

Custom knock-in cell lines for the dTAG and aTAG platforms are available from Bio-Techne .

Specifications

Chemical Name or Material 6-(6-((4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)carbamoyl)pyridin-3-yl)-N-methyl-4-(phenylamino)quinoline-3-carboxamide
CAS 2387510-81-6
Quantity 5 mg
Target TAG Degradation Platforms
Molecular Formula C42H38N8O8
Purity 98%
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.