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ATF1 Mouse anti-Human, Clone: OTI7H3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526909

Catalog No. PIMA526909


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Description

Description

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.
Specifications

Specifications

ATF1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P18846
EWS-ATF1, FUS/ATF-1, TREB36, cAMP-dependent transcription factor ATF-1, cyclic AMP-dependent transcription factor ATF-1
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
466
Immunohistochemistry (Paraffin), Western Blot
OTI7H3
Unconjugated
ATF1
Liquid
ATF1
Full length human recombit protein of ATF1 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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