ATF2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA586110

Catalog No. PIPA586110

Description

The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. ATF-2 interacts with a variety of viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways. Various forms of cellular stress, including genotoxic agents, inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF-2. Cellular stress activates ATF-2 by phosphorylation of Thr69 and Thr71. Both SAPK and p38 MAPK have been shown to phosphorylate ATF-2 at these sites in vitro and in cells transfected with ATF-2.

Specifications

• Antigen: ATF2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Atf2
• Gene Alias: Activating 2, Activating transcription factor 2, activating transcription factor 2 splice variant ATF2-var2, ATF2, Atf-2, cAMP response element-binding protein CRE-BP1, cAMP responsive element binding protein 2, formerly, cAMP-dependent transcription factor ATF-2, CREB2, CREB-2, CRE-BP, CREBP1, CRE-BP1, Cyclic AMP-dependent transcription factor ATF-2, cyclic AMP-responsive element-binding protein 2, D130078H02Rik, D18875, HB16, Histone acetyltransferase ATF2, MGC111558, mXBP, MXBP protein, OTTHUMP00000205345, OTTHUMP00000205347, OTTHUMP00000205348, OTTHUMP00000205350, OTTHUMP00000205352, OTTHUMP00000205353, OTTHUMP00000205354, Tg(Gzma-Klra1)7Wum, TREB7
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11909, 1386, 81647
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
• Gene Accession No.: P15336, P16951, Q00969
• Gene Symbols: Atf2
• Immunogen: Synthetic peptide, corresponding to amino acids 20-70 of Human ATF2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG