ATF7 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA549790
The antibody detects endogenous levels of total ATF7 protein.Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5 ft.-GTGACGT[AG][AG]-3 ft.), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0acts as a domit repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation. Gaire M., Nucleic Acids Res. 18:3467-3473(1990). Chatton B., Submitted (DEC-1990) to the EMBL/GenBank/DDBJ databases. Olsen J.V., Cell 127:635-648(2006).
|Synthesized peptide derived from internal of human ATF7.|
|Antigen affinity chromatography|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.4|
|ATFA, activating transcription factor 7, cyclic AMP-dependent transcription factor ATF-7,|
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