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ATG12 Mouse anti-Human, Mouse, Clone: GT166, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527801

Catalog No. PIMA527801


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Description

Description

Positive Control: 293T, A431, HeLa, HepG2, Neuro2A, GL261, C8D30, NIH-3T3, BCL-1, Raw264.7, C2C12 Predicted Reactivity: Pig (81%), Chimpanzee (96%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

ATG12, a member of the autophagy protein family, forms a conjugate with ATG5 this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist. Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1.
Specifications

Specifications

ATG12
Monoclonal
1 mg/ml
PBS with no preservative
O94817, Q9CQY1
APG12L, FBR93, autophagy related 12, HAPG12, APG12
Mouse
IgG2b
100 μl
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
67526, 9140
Immunocytochemistry, Immunofluorescence, Western Blot
GT166
Unconjugated
ATG12
Liquid
Atg12
Recombit protein encompassing a sequence within the center region of human ATG12. The exact sequence is proprietary.
Protein G
RUO
Antibody
Monoclonal
Human, Mouse
Documents
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