Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
ATG13 Mouse anti-Human, Clone: OTI1B1, liquid, TrueMAB™
Mouse Monoclonal Antibody
Supplier: OriGene TA810065
SDSDocumentsProduct Certifications Promotions
DescriptionAutophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG13 forms a complex with ULK1 and ULK2, the mammalian homologs of ATG1, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions; inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. Knockdown of ATG13 inhibits autophagosome formation.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|Human recombit protein fragment corresponding to amino acids 285-364 of human ATG13 produced in E.coli.|
|-20° C, Avoid Freeze/Thaw Cycles|
Provide Content Correction
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok