ATG13 Mouse anti-Human, Clone: OTI1B1, liquid, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene TA810065

Catalog No. 50-168-3176

Description

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG13 forms a complex with ULK1 and ULK2, the mammalian homologs of ATG1, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions; inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. Knockdown of ATG13 inhibits autophagosome formation.

Specifications

• Antigen: ATG13
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O75143
• Gene Symbols: ATG13
• Immunogen: Human recombit protein fragment corresponding to amino acids 285-364 of human ATG13 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI1B1
• Conjugate: Unconjugated
• Gene: ATG13
• Gene Alias: KIAA0652, PARATARG8
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9776
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid