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ATG3 Mouse anti-Human, Clone: OTI2C12, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525610

Catalog No. PIMA525610


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Description

Description

ATG3 (APG3) is a widely expressed conjugating enzyme for APG8 lipidation, an essential step for the initiation of autophagy. Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Autophagy is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG3 functions as an E2-like enzyme during the initial stages of autophagosome formation by catalyzing the formation of the Atg8-phosphatidylethanolamine (Atg8-PE) conjugate, which is critical for autophagy.
Specifications

Specifications

ATG3
Monoclonal
0.39 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9NT62
2610016C12Rik; APG3 autophagy 3-like; autophagy Apg3p/Aut1p-like; autophagy-related protein 3; hApg3; ubiquitin-like-conjugating enzyme ATG3
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
64422
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI2C12
Unconjugated
ATG3
Liquid
ATG3
Full length human recombit protein of ATG3 produced in HEK293 cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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