ATG4C Polyclonal Antibody, Invitrogen™
Sheep Polyclonal Antibody
Supplier: Thermo Scientific OSA00004W
Reconstitute with 150 μL of distilled water. Centrifuge to remove any insoluble material.Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some maligt tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Highly expressed in skeletal muscle, heart, liver and testis.;
|ATG4C, autophagin-3, APG4C, AUTL1, AUTL3, APG4-C, FLJ14867, ATG4 autophagy related 4 homolog C (S. cerevisiae), Autophagy-related protein 4 homolog C,
|Human, Mouse, Rat
|Immunohistochemistry, Western Blot
|A synthetic peptide from human, rat, mouse human, rat, mouse cysteine protease ATG4C
|242557, 313391, 84938
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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