ATRX Mouse anti-Human, Clone: 60.1, Abnova™
Mouse monoclonal antibody raised against synthetic peptide of human ATRX.
Manufacturer: Abnova Corporation MAB12915
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
|Mouse monoclonal antibody raised against synthetic peptide of human ATRX.|
|In PBS, pH 7.2.|
|Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|ELISA, Immunohistochemistry (PFA fixed), Western Blot|
|ELISA Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 ug/mL) Western Blot The optimal working dilution should be determined by the end user.|
|A mixture of synthetic peptides corresponding to residues within 1-300 and 450-741 of human ATRX.|
|Protein G purification|
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