ATRX Mouse anti-Human, Mouse, Clone: GT4212, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527732
Positive Control: 293T, Neuro2A, C8D30, BCL-1 Predicted Reactivity: Chimpanzee (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.ATRX encodes a protein that contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
|PBS with no preservative|
|Recombit protein encompassing a sequence within the C-terminus region of human ATRX. The exact sequence is proprietary.|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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