ATRX, Polyclonal, Bethyl Laboratories
Rabbit Polyclonal Antibody
Manufacturer: Bethyl Laboratories, Inc A301045AT
The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predictThe protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
|TBS with 0.1% BSA and 0.09% sodium azide|
|RP5-875J14.1, ATR2, JMS, MRXHF1, RAD54, RAD54L, SFM1, SHS, XH2, XNP, ZNF-HX, ATP-dependent helicase ATRX, DNA dependent ATPase and helicase, RAD54 homolog, X-linked helicase II, X-linked nuclear protein, Zinc finger helicase, alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae), helicase 2, X-linked, transcriptional regulator ATRX|
|Immunohistochemistry, Western Blot|
|Between 2442 and C-term|
|Antigen affinity chromatography|
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