Tocris AZ 10417808
Selective non-peptide caspase-3 inhibitor
Manufacturer: Tocris 2172/10
DescriptionSelective non-peptide inhibitor of caspase-3 (Ki = 247nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10µM). Completely blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells (IC50 = 14.9µM).
- Chemical Name: 2-[(3,4-Dichlorophenyl)amino]-1,4-dihydro-6-nitro-4-oxo-N-2-propenyl-8-quinazolinecarboxamide
- Formula: C18H13Cl2N5O4
- CAS Number: 331645-84-2
- Solubility: Soluble to 25mM in DMSO
- Purity: >98
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