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Tocris Bioscience™ AZ 12799734

Potent TGF-βRI inhibitor

Manufacturer:  Tocris Bioscience™ 6870/10

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Catalog No. 68-701-0


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Description

Description

AZ 12799734 is a potent inhibitor of transforming growth factor-β type I receptor (TGF-βRI; ALK5) (IC50 = 17 nM in cellular inhibition assay and 47 nM in TGF-β-induced luciferase activity assay). Also inhibits ALK4, ALK6 and ALK7 at concentrations under 10 μM. Inhibits BMP signaling, phosphorylation of SMAD1 and SMAD2, and TGF-β-induced epithelial cell migration in vitro. Displays cardiotoxicity in vivo. Orally bioavailable.
Specifications

Specifications

C18H18N4O3S
4-[[4-[(2.6-Dimethyl-3-pyridinyl)oxy]-2-pyridinyl]amino]benzenesulfonamide
10 mg
98%
1117684-36-2
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