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Tocris Bioscience™ AZ 12799734

Potent TGF-βRI inhibitor

$215.50 - $908.50

Specifications

CAS 1117684-36-2
Chemical Name or Material 4-[[4-[(2.6-Dimethyl-3-pyridinyl)oxy]-2-pyridinyl]amino]benzenesulfonamide
Molecular Formula C18H18N4O3S
Purity 98%
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
68-701-0
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Tocris Bioscience™
6870/10
10 mg
Each for $215.50
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68-705-0
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Tocris Bioscience™
6870/50
50 mg
Each for $908.50
Add to cart
 
Description

Description

  • Potent inhibitor of transforming growth factor-β type I receptor (TGF-βRI; ALK5) (IC50 = 17 nM in cellular inhibition assay and 47 nM in TGF-β-induced luciferase activity assay).
  • Also inhibits ALK4, ALK6 and ALK7 at concentrations under 10 μM.
  • Inhibits BMP signaling, phosphorylation of SMAD1 and SMAD2, and TGF-β-induced epithelial cell migration in vitro.
  • Displays cardiotoxicity in vivo.
  • Orally bioavailable.
Specifications

Specifications

1117684-36-2
4-[[4-[(2.6-Dimethyl-3-pyridinyl)oxy]-2-pyridinyl]amino]benzenesulfonamide
C18H18N4O3S
98%
SDS
Product Certifications
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