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Tocris Bioscience™ AZD 3988

Potent and selective DGAT-1 inhibitor

Supplier:  Tocris Bioscience™ 4837/50

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Catalog No. 48-375-0


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Description

Description

AZD 3988 is a potent and selective diacylglycerol acyltransferase (DGAT-1) inhibitor (IC50 = 0.6 nM). Exhibits selectivity for DGAT-1 over DGAT-2, Kv11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable.
Specifications

Specifications

>98%
AZD 3988
AZD 3988
50 mg
456.44
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