Tocris™ AZD 3988

Potent and selective DGAT-1 inhibitor

Manufacturer: Tocris™ 4837/50

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Catalog No. 48-375-0

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For Research Use Only


    Specifications

    Product Type AZD 3988
    Inhibitors AZD 3988
    Purity >98
    Molecular Weight 456.44
    Quantity 50mg

    Potent and selective diacylglycerol acyltransferase (DGAT-1) inhibitor (IC50 = 0.6nM). Exhibits selectivity for DGAT-1 over DGAT-2, Kv11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable.

    • Chemical Name: trans-4-[-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid
    • Formula: C23H22F2N4O4
    • CAS Number: 892489-52-0
    • Solubility: Soluble to 100mM in DMSO and to 10mM in 1eq. NaOH with gentle warming
    • Purity: >98

  • Description & Specifications

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