Tocris AZD 3988
Potent and selective DGAT-1 inhibitor
Manufacturer: Tocris 4837/10
DescriptionPotent and selective diacylglycerol acyltransferase (DGAT-1) inhibitor (IC50 = 0.6nM). Exhibits selectivity for DGAT-1 over DGAT-2, Kv11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable.
- Chemical Name: trans-4-[-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid
- Formula: C23H22F2N4O4
- CAS Number: 892489-52-0
- Solubility: Soluble to 100mM in DMSO and to 10mM in 1eq. NaOH with gentle warming
- Purity: >98
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