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  8. AZD 5438, Tocris Bioscience™

AZD 5438, Tocris Bioscience™

Catalog Number 396810
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
602306-29-6
C18H21N5O2S
371.459
WJRRGYBTGDJBFX-UHFFFAOYSA-N
4-1-isopropyl-2-methyl-1h-imidazol-5-yl-n-4-methylsulfonyl phenyl pyrimidin-2-amine, 2-pyrimidinamine,4-2-methyl-1-1-methylethyl-1h-imidazol-5-yl-n-4-methylsulfonyl phenyl, 4-2-methyl-1-isopropyl-1h-imidazol-5-yl-n-4-methylsulfonyl phenyl-2-pyrimidinamine, 4-2-methyl-3-propan-2-ylimidazol-4-yl-n-4-methylsulfonylphenyl pyrimidin-2-amine, 4-3-isopropyl-2-methylimidazol-4-yl-n-4-methanesulfonylphenyl pyrimidin-2-amine, pubchem19336, d06why, 4-2-methyl-1-1-methylethyl-1h-imidazol-5-yl-n-4-methylsulfonyl phenyl-2-pyrimidinamine, 4-1-isopropyl-2-methylimidazol-5-yl-2-4-mesylanilino pyrimidine
16747683
4-(2-methyl-3-propan-2-ylimidazol-4-yl)-N-(4-methylsulfonylphenyl)pyrimidin-2-amine
CC1=NC=C(N1C(C)C)C2=NC(=NC=C2)NC3=CC=C(C=C3)S(=O)(=O)C
This item is not returnable. View return policy
602306-29-6
C18H21N5O2S
371.459
WJRRGYBTGDJBFX-UHFFFAOYSA-N
4-1-isopropyl-2-methyl-1h-imidazol-5-yl-n-4-methylsulfonyl phenyl pyrimidin-2-amine, 2-pyrimidinamine,4-2-methyl-1-1-methylethyl-1h-imidazol-5-yl-n-4-methylsulfonyl phenyl, 4-2-methyl-1-isopropyl-1h-imidazol-5-yl-n-4-methylsulfonyl phenyl-2-pyrimidinamine, 4-2-methyl-3-propan-2-ylimidazol-4-yl-n-4-methylsulfonylphenyl pyrimidin-2-amine, 4-3-isopropyl-2-methylimidazol-4-yl-n-4-methanesulfonylphenyl pyrimidin-2-amine, pubchem19336, d06why, 4-2-methyl-1-1-methylethyl-1h-imidazol-5-yl-n-4-methylsulfonyl phenyl-2-pyrimidinamine, 4-1-isopropyl-2-methylimidazol-5-yl-2-4-mesylanilino pyrimidine
16747683
4-(2-methyl-3-propan-2-ylimidazol-4-yl)-N-(4-methylsulfonylphenyl)pyrimidin-2-amine
CC1=NC=C(N1C(C)C)C2=NC(=NC=C2)NC3=CC=C(C=C3)S(=O)(=O)C

Description

Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9

Potent inhibitor of cyclin dependent kinases (cdks; reported IC50 values are 6 - 45, 14, 16 and 20 nM for cdk2, cdk5, cdk1 and cdk9 respectively). Also inhibits cdk4 and cdk7 in the sub micromolar range. Exhibits antiproliferative activity in human tumor cell lines. Blocks cell cycling at G2-M, S and G1 phases; reduces the proportion of actively cycling cells in vivo.
Quantity 10 mg
Formula Weight 371.46
Percent Purity >99%
Chemical Name or Material AZD 5438

Safety and Handling

Recommended Storage Desiccate at Room Temperature
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