B-Raf Rabbit anti-Human, Invitrogen
Rabbit Recombinant Monoclonal Antibody
Manufacturer: Invitrogen MA524661
This antibody reacts to the BRAF V600E mutant. No cross reactivity with wild type BRAF. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using Recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.B-raf belongs to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in the gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, maligt melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.
|PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH 7.2-7.4|
|Peptide corresponding to B-Raf V600E mutant.|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|-20° C, Avoid Freeze/Thaw Cycles|
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