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B7-1/CD80, Human anti-Human, Clone: IDEC-114 (Galiximab), Novus Biologicals™
Human Monoclonal Antibody
Supplier: Novus Biologicals NBP2810990.025MG
Description
B7-1/CD80 Monoclonal specifically detects B7-1/CD80 in Human samples. It is validated for Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunoprecipitation, Functional, Block/Neutralize.Specifications
B7-1/CD80 | |
Monoclonal | |
1 mg/mL | |
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunoprecipitation, Block/Neutralize | |
Activation B7-1 antigen, B7, BB1, CD28LG1, CD28LGB7-1 antigen), CD80 antigen, CD80 molecule, costimulatory factor CD80, costimulatory molecule variant IgV-CD80, CTLA-4 counter-receptor B7.1, T-lymphocyte activation antigen CD80 | |
Human | |
Protein A purified | |
RUO | |
Primary | |
Galiximab is a primatized mAb which consists of human constant and primate (cynomolgus macaque) variable regions and binds specifically to B7-1/CD80. B7-1/CD80 is a surface glycoprotein and a member of the B7 family of costimulatory molecules. B7-1/CD80 antigen regulates T cell activation (through interacting with CD28 or CD152) and is expressed transiently in antigen-presenting cells, T cells and normal B cells, and expressed consitutively on various subtypes of B-cell lymphomas. | |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. | |
IgG1 λ |
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunoprecipitation, Blocking Assay | |
IDEC-114 (Galiximab) | |
Unconjugated | |
PBS | |
CD80 | |
Galiximab was prepared by immunizing cynomolgus monkeys with recombinant B7-1/CD80 antigen. The variable regions of the light and heavy chains were then cloned by being incorporated into a cassette vector (N5LG1) containing human constant region genes and subsequently transfected into the Dg44 CHO cell line (Hariharan K, 2013) | |
0.025 mg | |
Adaptive Immunity, B Cell Development and Differentiation Markers, Cytokine Research, Immunology, Signal Transduction | |
941 | |
Human | |
Purified |
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