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B7-1/CD80, Rabbit anti-Human, Clone: IDEC-114 (Galiximab), Novus Biologicals™

Rabbit Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP2811000.025MG

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Catalog No. NB016063


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Description

Description

B7-1/CD80 Monoclonal specifically detects B7-1/CD80 in Human samples. It is validated for Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Functional, Block/Neutralize.
Specifications

Specifications

B7-1/CD80
IDEC-114 (Galiximab)
Unconjugated
PBS
Activation B7-1 antigen, B7, BB1, CD28LG1, CD28LGB7-1 antigen), CD80 antigen, CD80 molecule, costimulatory factor CD80, costimulatory molecule variant IgV-CD80, CTLA-4 counter-receptor B7.1, T-lymphocyte activation antigen CD80
Rabbit
IgG Lambda
0.025 mg
Adaptive Immunity, B Cell Development and Differentiation Markers, Cytokine Research, Immunology, Signal Transduction
Primary
941
Human
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunoprecipitation, Functional Assay, Blocking Assay
1 mg/mL
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunoprecipitation, Functional, Block/Neutralize
Purified
CD80
Galiximab was prepared by immunizing cynomolgus monkeys with recombinant B7-1/CD80 antigen. The variable regions of the light and heavy chains were then cloned by being incorporated into a cassette vector (N5LG1) containing human constant region genes and subsequently transfected into the Dg44 CHO cell line (Hariharan K, 2013)
Protein A purified
RUO
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Monoclonal
Galiximab is a primatized mAb which consists of human constant and primate (cynomolgus macaque) variable regions and binds specifically to B7-1/CD80. B7-1/CD80 is a surface glycoprotein and a member of the B7 family of costimulatory molecules. B7-1/CD80 antigen regulates T cell activation (through interacting with CD28 or CD152) and is expressed transiently in antigen-presenting cells, T cells and normal B cells, and expressed consitutively on various subtypes of B-cell lymphomas.
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