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B7-H3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA551098

Catalog No. PA551098


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Description

Description

B7-H3 / CD276 Polyclonal Antibody detects endogenous levels of B7-H3 / CD276 protein.

CD276 is a member of the B7 family of co-stimulatory molecules also known as B7-H3. CD276 is a type I transmembrane protein that induces the proliferation of CD4+ and CD8+ T cells, enhances the generation of cytotoxic T cells and selectively stimulates the production of interferon gamma. Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines, and is also widely expressed in peripheral tissues including the heart, kidney, testis and colon. In humans, CD276 exists as two isoforms which result from gene duplication and differential splicing. CD276 is reported to have therapeutic potential for the regulation of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy.
Specifications

Specifications

B7-H3
Polyclonal
Unconjugated
CD276
Liquid
CD276
Synthesized peptide derived from the Internal region of human CD276.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
ELISA, Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Q5ZPR3, Q8VE98, Q7TPB4
B7H3B7H3; HB7H3
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
102657, 315716, 80381
Documents
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