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BABAM1 Mouse anti-Human, Clone: GT2810, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527831

Catalog No. PIMA527831


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Description

Description

Positive Control: 293T, A431, HeLa, HepG2 Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Component of the BRCA1-A complex, a complex that specifically recognizes  ft.Lys-63 ft.-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes  ft.Lys-63 ft.-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves  ft.Lys-63 ft.-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the  ft.Lys-63 ft.-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.
Specifications

Specifications

BABAM1
Monoclonal
1 mg/ml
PBS with no preservative
Q9NWV8
BRISC and BRCA1 A complex member 1, BABAM1, HSPC142, NBA1, MERIT40
Mouse
IgG2b
100 μl
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
29086
Immunocytochemistry, Immunofluorescence, Western Blot
GT2810
Unconjugated
BABAM1
Liquid
BABAM1
Recombit protein encompassing a sequence within the N-terminus region of human C19orf62. The exact sequence is proprietary.
Protein G
RUO
Antibody
Monoclonal
Human
Documents
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