BABAM1 Mouse anti-Human, Clone: GT2810, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527831
Positive Control: 293T, A431, HeLa, HepG2 Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Component of the BRCA1-A complex, a complex that specifically recognizes ft.Lys-63 ft.-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ft.Lys-63 ft.-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves ft.Lys-63 ft.-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the ft.Lys-63 ft.-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.
|PBS with no preservative|
|BRISC and BRCA1 A complex member 1, BABAM1, HSPC142, NBA1, MERIT40|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|Recombit protein encompassing a sequence within the N-terminus region of human C19orf62. The exact sequence is proprietary.|
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