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Tocris™ BAG 956

Dual PI 3-kinase and PDK1 inhibitor

Manufacturer:  Tocris™ 3606/50

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Catalog No. 36-065-0R

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For Research Use Only



Dual PDK1 and class I PI 3-K inhibitor (IC50 values are 245, 56, 446, 35 and 117nM for PDK1 and PI 3-K p110 -α, -β, -δ, and -γ respectively). Inhibits cellular AKT phosphorylation at Thr308. Blocks cell proliferation, causing arrest in G1 phase of the cell cycle. Slows tumor progression in mouse xenograft models.
  • Chemical Name: α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile
  • Formula: C28H21N5
  • CAS Number: 853910-02-8
  • Solubility: Soluble to 40mM in DMSO and to 20mM in ethanol
Description & Specifications


BAG 956
BAG 956
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