Tocris BAG 956
Dual PI 3-kinase and PDK1 inhibitor
Manufacturer: Tocris 3606/10
DescriptionDual PDK1 and class I PI 3-K inhibitor (IC50 values are 245, 56, 446, 35 and 117nM for PDK1 and PI 3-K p110 -α, -β, -δ, and -γ respectively). Inhibits cellular AKT phosphorylation at Thr308. Blocks cell proliferation, causing arrest in G1 phase of the cell cycle. Slows tumor progression in mouse xenograft models.
- Chemical Name: α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile
- Formula: C28H21N5
- CAS Number: 853910-02-8
- Solubility: Soluble to 40mM in DMSO and to 20mM in ethanol
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