BAG4 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA141302

Catalog No. 01-675-642

Description

Suggested positive control: Hela whole cell extract, HeLa cell lysate.

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.

Specifications

• Antigen: BAG4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BAG4
• Gene Alias: 2410112I15Rik; BAG cochaperone 4; BAG family molecular chaperone regulator 4; BAG4; BAG-4; BAG-family molecular chaperone regulator-4; BCL2 associated athanogene 4; Bcl-2-associated athanogene 4; BCL2-associated athanogene 4; silencer of death domains; SODD
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 9530
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.2% gelatin and 0.05% sodium azide
• Gene Accession No.: O95429
• Gene Symbols: BAG4
• Immunogen: Synthetic peptide corresponding to residues 443-457 of human SODD.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG