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Tocris™ Banoxantrone dihydrochloride

Prodrug topoisomerase II inhibitor

Manufacturer:  Tocris™ 4219/50

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Catalog No. 42-195-0


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Disclaimers:

For Research Use Only


Specifications

Description

Bioreductive prodrug; activated by hypoxia to yield the topoisomerase II inhibitor AQ4. Displays little to no cytotoxic activity against 60 tumor cell lines tested under oxic conditions (IC50 >100µM). Exhibits anti-tumor efficacy in vivo when combined with oxic cell cytotoxins; enhances the anti-tumor effect of cyclophosphamide (Cat. No. 4091) in a mouse tumor model.
  • Chemical Name: 1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride
  • Formula: C22H28N4O6.2HCl
  • CAS Number: 252979-56-9
  • Solubility: Soluble to 50mM in water and to 25mM in DMSO)
  • Purity: >98
Description & Specifications

Specifications

Banoxantrone dihydrochloride
>98
50mg
Banoxantrone dihydrochloride
517.4
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