Tocris™ Banoxantrone dihydrochloride

Prodrug topoisomerase II inhibitor

Manufacturer: Tocris™ 4219/10

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Catalog No. 42-191-0

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For Research Use Only


    Product Type Banoxantrone dihydrochloride
    Inhibitors Banoxantrone dihydrochloride
    Purity >98
    Molecular Weight 517.4
    Quantity 10mg

    Bioreductive prodrug; activated by hypoxia to yield the topoisomerase II inhibitor AQ4. Displays little to no cytotoxic activity against 60 tumor cell lines tested under oxic conditions (IC50 >100µM). Exhibits anti-tumor efficacy in vivo when combined with oxic cell cytotoxins; enhances the anti-tumor effect of cyclophosphamide (Cat. No. 4091) in a mouse tumor model.

    • Chemical Name: 1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride
    • Formula: C22H28N4O6.2HCl
    • CAS Number: 252979-56-9
    • Solubility: Soluble to 50mM in water and to 25mM in DMSO)
    • Purity: >98

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