Tocris Banoxantrone dihydrochloride
Prodrug topoisomerase II inhibitor
Manufacturer: Tocris 4219/10
DescriptionBioreductive prodrug; activated by hypoxia to yield the topoisomerase II inhibitor AQ4. Displays little to no cytotoxic activity against 60 tumor cell lines tested under oxic conditions (IC50 >100µM). Exhibits anti-tumor efficacy in vivo when combined with oxic cell cytotoxins; enhances the anti-tumor effect of cyclophosphamide (Cat. No. 4091) in a mouse tumor model.
- Chemical Name: 1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride
- Formula: C22H28N4O6.2HCl
- CAS Number: 252979-56-9
- Solubility: Soluble to 50mM in water and to 25mM in DMSO)
- Purity: >98
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