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Bax Mouse anti-Human, Mouse, Non-human primate, Rat, Clone: 6A7, eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

$209.00

Specifications

Antigen Bax
Clone 6A7
Target Species Human, Mouse, Non-human primate, Rat
Conjugate Unconjugated
Isotype IgG1
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Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-135-81 Non-distribution product as customer accommodation.
View Documents
Invitrogen
14699782
100 μg
Each for $209.00
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Description

Description

Description: The 6A7 antibody reacts with mouse, rat, monkey and human Bax (20 kDa). The 6A7 antibody shows no cross-reaction with Bcl-2 or Bcl-xL proteins. Bcl-2, Bax, and Bcl-xL are members of a protein family that regulates apoptosis; while several family members including Bcl-2 and Bcl-xL inhibit apoptosis, overexpression of Bax promotes programmed cell death. A human Bax protein peptide sequence, aa 12-24, was used as immunogen. Applications Reported: The 6A7 antibody has been reported for use in immunoblotting (WB). Applications Tested: The 6A7 antibody has been tested by Western Blot and can be used at approximately 1 µg/mL. It is recommended that the reagent be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 µm post-manufacturing filtered.

BAX is a members of the Bcl-2 Family and plays an important role in regulation of apoptosis. Whereas Bcl-2 is commonly regarded as an anti-apoptotic protein, BAX is considered to have a pro-apoptotic function. Regulation of apoptosis is supposed to involve both homo- and heterodimerization of different isoforms of BAX and Bcl-2. The Bax gene encodes different isoforms including Bax alpha (21 kDa) and Bax beta (24 kDa), whereas both isoforms contain the BH1, BH2 and BH3 domains, Bax beta has a unique carboxyl terminus and does not contain a hydrophobic transmembrane domain. Bcl-2 is also expressed in different Isoforms. Bcl-2 beta differs in the 3 ft. UTR and coding region compared to variant alpha. Bcl-2 beta is shorter (22 kDa) and has a distinct C-terminus compared to Bcl-2 alpha (26 kDa). BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.
Specifications

Specifications

Bax
Human, Mouse, Non-human primate, Rat
IgG1
Monoclonal
Liquid
Antibody
4° C
6A7
Unconjugated
Western Blot
Primary
Monoclonal
PBS with 0.09% sodium azide; pH 7.2
RUO
SDS

For Research Use Only.

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