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Tocris Bioscience™ BAY 598

Potent and selective SMYD2 inhibitor

Manufacturer:  Tocris Bioscience™ 5991/25

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Catalog No. 59-912-5

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Potent and selective competitive inhibitor of SMYD2 lysine methyltransferase (IC50 values are 27 and 58 nM for biochemical and cellular activity assays, respectively). Displays >100-fold selectivity for SMYD2 over a panel of 32 other methyltransferases including SMYD3, SUV420H1, and SUV420H2. Enhances apoptotic responses to doxorubicin (Cat. No. 2252) in cancer cell lines. Decreases p53K370me levels in HEK293 cells. Reduces methylation in tumor cells in a mouse xenograft model.

To request the negative control for BAY 598, please fill out the BAY 369 request form on the SGC website.



25 mg
Safety and Handling

Safety and Handling

Recommended Storage : Store at -20°C

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