DescriptionTIP 5 is the large subunit of the nucleolar remodeling complex NoRC. NoRC causes the repression of ribosomal gene transcription. It was demonstrated that histone deacetylation is involved in this repression and that TIP5 is associated with the histone deacetylase HDAC1 and mediates the deacetylation of histones in the vicinity of the rDNA promoter. The interaction of TIP5 and HDAC1, which is necessary for transcriptional repression, is established by the C-terminal PHD finger and bromodomain.
|This antibody was raised against a peptide within the N-terminal region of human BAZ2A.|
|-20°C, Avoid Freeze/Thaw Cycles|
|PBS with 30% glycerol and 0.035% sodium azide; pH 7.5|
|AA415431; BAZ2A; bromodomain adjacent to zinc finger domain 2A; Bromodomain adjacent to zinc finger domain protein 2A; bromodomain adjacent to zinc finger domain, 2A; C030005G16Rik; C78388; hWALp3; KIAA0314; mKIAA0314; TIP5; Transcription termination factor I-interacting protein 5; TTF-I interacting peptide 5; TTF-I-interacting protein 5; Walp3|
|Antigen affinity chromatography|
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